Novel fumarate derivatives; synthesis and investigation of acetylcholinesterase inhibitor properties

In this study, new fumarate compounds (I-IV) containing some natural phenols (eugenol, guaiacol, isoeugenol and vanillin) were synthesized characterized. The single crystal X-ray diffraction technique was used to determine the structures of all compounds. All evaluated as acetylcholinesterase (AChE) inhibitory, especially compound IV (IC50 =5.25±0.51 µg/mL), can be identified a promising anti-acetylcholinesterase agent due its good inhibitory effect, when compared with donepezil hydrochloride =16.02±0.66 µg/mL) standard agent.